Epileptiform discharges induced by combined application of bicuculline and 4-aminopyridine are resistant to standard anticonvulsants in slices of rats
1999; Elsevier BV; Volume: 268; Issue: 3 Linguagem: Inglês
10.1016/s0304-3940(99)00341-9
ISSN1872-7972
AutoresChristopher Brückner, K. Stenkamp, H. Meierkord, Uwe Heinemann,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoApplication of 4-aminopyridine (4AP) has previously been reported to produce different patterns of epileptiform discharges in entorhinal cortex-hippocampal-slices. Here we describe that 4-AP induced epileptiform activity in the EC becomes insensitive to anticonvulsant drugs (phenytoin, carbamazepine, valproic acid, phenobarbital) when GABAergic transmission is blocked by bicuculline. We propose that the activities induced by 4-aminopyridine and bicuculline may provide an in vitro model for the development of new drugs against difficult-to-treat focal epilepsy.
Referência(s)