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A New Gun in Town: The U Box Is a Ubiquitin Ligase Domain

2002; American Association for the Advancement of Science; Volume: 2002; Issue: 116 Linguagem: Inglês

10.1126/stke.2002.116.pe4

1525-8882

Cam Patterson,

Genetics and Neurodevelopmental Disorders

Ubiquitin ligases determine protein stability in a highly regulated manner by coordinating the addition of polyubiquitin chains to proteins that are then targeted to the proteasome for degradation. Ubiquitin ligases have generally been separated into two groups--those containing HECT domains and those with RING finger domains. Recently, a third group of ubiquitin ligases has emerged: those containing a U-box domain. Patterson discusses what is known about the few U-box-containing proteins that have been characterized, although the general properties of U-box proteins that distinguish them from other ubiquitin ligases are still a matter of speculation.