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Catalytic Asymmetric Hydroxylation of Oxindoles by Molecular Oxygen Using a Phase-Transfer Catalyst

2008; American Chemical Society; Volume: 10; Issue: 8 Linguagem: Inglês

10.1021/ol800260r

1523-7060

Daisuke Sano, Kazuhiro Nagata, Takashi Itoh,

Axial and Atropisomeric Chirality Synthesis

The highly enantioselective catalytic hydroxylation of 3-substituted oxindoles was achieved by using a phase-transfer catalyst with molecular oxygen as an oxidant. The product then was converted to an optically active compound 8, which was a synthetic precursor of alkaloid CPC-1.