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Cost-Effectiveness of Alendronate Therapy for Osteopenic Postmenopausal Women

2005; American College of Physicians; Volume: 142; Issue: 9 Linguagem: Inglês

10.7326/0003-4819-142-9-200505030-00008

1539-3704

John T. Schousboe, John A. Nyman, Robert L Kane, Kristine E. Ensrud,

Cardiac, Anesthesia and Surgical Outcomes

Treatment guidelines recommend drug treatment to prevent fractures for some postmenopausal women who have low bone mass (osteopenia) but do not have osteoporosis or a history of clinical fractures.To estimate the societal costs and health benefits of alendronate drug treatment to prevent fractures in postmenopausal women with osteopenia.Markov model with 8 health states: no fracture, post-distal forearm fracture, post-clinical vertebral fracture, post-radiographic (but clinically inapparent) vertebral fracture, post-hip fracture, post-hip and vertebral fractures, post-other fracture, and death.Population-based studies of age-specific fracture rates and costs, prospectively measured estimates of disutility after fractures, and the Fracture Intervention Trial of alendronate versus placebo to prevent fracture.Postmenopausal women 55 to 75 years of age with femoral neck T-scores between -1.5 and -2.4.Lifetime.Societal.Five years of alendronate therapy or no drug treatment.Costs, quality-adjusted life-years, and incremental cost-effectiveness ratios.For women with no additional fracture risk factors, the cost per quality-adjusted life-year gained ranged from 70,000 dollars to 332,000 dollars, depending on age and femoral neck bone density.Results were sensitive to changes in fracture risk reduction attributable to alendronate and alendronate cost.Results apply only to postmenopausal white women residing in the United States.Alendronate therapy for postmenopausal women with femoral neck T-scores better than -2.5 and no history of clinical fractures or other bone mineral density-independent risk factors for fracture is not cost-effective, assuming U.S. costs of alendronate and currently available estimates of alendronate efficacy in osteopenic women.