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Physiologic aspects of anemia

2004; Elsevier BV; Volume: 20; Issue: 2 Linguagem: Inglês

10.1016/j.ccc.2004.01.001

1557-8232

Paul C. Hébert, Phillipe Van der Linden, George P. Biro, Ling‐Qun Hu,

Trauma, Hemostasis, Coagulopathy, Resuscitation

Many of the physiological concepts in oxygen (O2) transport and use were described in the early part of the 20th century and are still widely accepted [ [1] Tuman K.J. Tissue oxygen delivery. The physiology of anemia. Anesthesiol Clin North America. 1990; 8: 451-469 Google Scholar ]. In 1920, Barcroft [ [2] Barcroft J. The respiratory function of the blood. Part I: lessons from high altitudes. Cambridge University Press, Cambridge (MA)1925 Google Scholar ] noted that tissue oxygenation was a function of hemoglobin concentration, oxygenation of blood by the lungs, and the cardiac output to deliver a supply of oxygenated blood to the tissues. Similarly, many of the principles underlying the transfer of O2 from the microcirculation to the mitochondria have been established and also have stood the test of time [ [1] Tuman K.J. Tissue oxygen delivery. The physiology of anemia. Anesthesiol Clin North America. 1990; 8: 451-469 Google Scholar ]. This article describes some of the basic principles of O2 transport that have been studied extensively and published in text books and review articles [ 1 Tuman K.J. Tissue oxygen delivery. The physiology of anemia. Anesthesiol Clin North America. 1990; 8: 451-469 Google Scholar , 3 Finch C.A. Lenfant C. Oxygen transport in man. N Engl J Med. 1972; 286: 407-415 Crossref PubMed Google Scholar , 4 Snyder J.V. Oxygen transport: the model and reality. in: Snyder J.V. Pinsky M.R. Oxygen transport in the critically ill. Year Book Medical Publishers, Chicago1987: 3-15 Google Scholar , 5 Schumacker P.T. Samsel R.W. Oxygen delivery and uptake by peripheral tissues: physiology and pathophysiology. Crit Care Clin. 1989; 5: 255-269 PubMed Google Scholar ]. It emphasizes the physiological consequences of anemia to provide information relevant to red cell transfusion decisions.