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Stereoselective Enzymatic Synthesis of Chiral Alcohols with the Use of a Carbonyl Reductase from Candida m agnoliae with Anti-Prelog Enantioselectivity

2006; American Chemical Society; Volume: 71; Issue: 11 Linguagem: Inglês

10.1021/jo0603328

1520-6904

Dunming Zhu, Yan Yang, Ling Hua,

Biochemical and Molecular Research

In our effort to search for carbonyl reductases with anti-Prelog enantioselectivity, the activity and enantioselectivity of a carbonyl reductase from Candida magnoliae have been examined with various ketones of diverse structures. This carbonyl reductase catalyzed the reduction of a series of ketones, α- and β-ketoesters, to anti-Prelog configurated alcohols in excellent optical purity. The usefulness of this carbonyl reductase has been demonstrated by synthesis of several chiral alcohol intermediates of pharmaceutical importance.