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Robust nonlinear state estimation of bioreactors based on H∞ hybrid observers

2013; Elsevier BV; Volume: 60; Linguagem: Inglês

10.1016/j.compchemeng.2013.09.013

1873-4375

Philippe Bogaerts, D. Coutinho,

Control Systems and Identification

This paper proposes a robust nonlinear observer for bioreactors combining the classical asymptotic observer and a nonlinear Luenberger-like observer. The resulting hybrid observer considers a new definition of the hybridization parameter which reflects the kinetic model confidence. The nonlinear observer is tuned on the basis of robust H-infinity approach and the differential-algebraic representation (DAR) of nonlinear systems. A simulated case study concerning fed-batch animal cell cultures is presented to demonstrate the potentials and advantages of the proposed approach for state estimation of bioreactors.