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Unsymmetrically disubstituted urea derivatives: A potent class of antiglycating agents

2009; Elsevier BV; Volume: 17; Issue: 6 Linguagem: Inglês

10.1016/j.bmc.2009.01.075

1464-3391

Khalid Mohammed Khan, Sumayya Saeed, Muhammad Ali, Madiha Gohar, Javariya Zahid, Ambreen Khan, Shahnaz Perveen, M. Iqbal Choudhary,

Parkinson's Disease Mechanisms and Treatments

A series of unsymmetrically disubstituted urea derivatives 1–28 has been synthesized and screened for their antiglycation activity in vitro. Compounds 26 (IC50 = 4.26 ± 0.25 μM), 1 (IC50 = 5.8 ± 0.08 μM), 22 (IC50 = 4.26 ± 0.25 μM), 6 (IC50 = 6.4 ± 0.02 μM), 5 (IC50 = 6.6 ± 0.26 μM), 2 (IC50 = 7.02 ± 0.31 μM), 3 (IC50 = 7.14 ± 0.84 μM), 27 (IC50 = 7.27 ± 0.36 μM), 4 (IC50 = 8.16 ± 1.04 μM), 21 (IC50 = 8.4 ± 0.15 μM), 23 (IC50 = 9.0 ± 0.35 μM) and 13 (IC50 = 15.22 ± 6.7 μM) showed an excellent antiglycation activity far better than the standard (rutin, IC50 = 41.9 ± 2.3 μM). This study thus provides a series of potential molecules for further studies of antiglycation agents.