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Paget disease of bone in a Jurassic dinosaur

2011; Elsevier BV; Volume: 21; Issue: 17 Linguagem: Inglês

10.1016/j.cub.2011.08.006

1879-0445

Florian Witzmann, Kerin M. Claeson, Oliver Hampe, Frank Wieder, André Hilger, Ingo Manke, Manuel Niederhagen, Bruce M. Rothschild, Patrick Asbach,

Bone Tumor Diagnosis and Treatments

Paget disease of bone — initially described by Sir James Paget in 1876 — is a benign bone disorder well known in human pathology. It leads to the enlargement and deformity of bones due to a combination of abnormal bone resorption and abundant new bone formation [1Smith S.E. Murphey M.D. Motamedi K. Mulligan M.E. Resnik C.S. Gannon F.H. From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation.Radiographics. 2002; 22: 1191-1216Crossref PubMed Scopus (146) Google Scholar, 2Dell'Atti C. Cassar-Pullicino V.N. Lalam R.K. Tins B.J. Tyrrell P.N.M. The spine in Paget's disease.Skeletal Radiol. 2007; 36: 609-626Crossref PubMed Scopus (51) Google Scholar, 3Roodman G.D. Windle J.J. Paget disease of bone.J. Clin. Invest. 2005; 115: 200-208Crossref PubMed Scopus (263) Google Scholar]. There is strong evidence that viruses are involved in the disease, coupled with a probable genetic component [3Roodman G.D. Windle J.J. Paget disease of bone.J. Clin. Invest. 2005; 115: 200-208Crossref PubMed Scopus (263) Google Scholar, 4Reddy S.V. Singer F.R. Roodman G.D. Bone marrow mononuclear cells from patients with Paget's disease contain measles virus nucleocapsid messenger ribonucleic acid that has mutations in a specific region of the sequence.J. Clin. Endocrinol. Metab. 1995; 80: 2108-2111Crossref PubMed Scopus (93) Google Scholar]. Paget disease in humans most frequently involves the skull, the spine and parts of the pelvis [1Smith S.E. Murphey M.D. Motamedi K. Mulligan M.E. Resnik C.S. Gannon F.H. From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation.Radiographics. 2002; 22: 1191-1216Crossref PubMed Scopus (146) Google Scholar, 2Dell'Atti C. Cassar-Pullicino V.N. Lalam R.K. Tins B.J. Tyrrell P.N.M. The spine in Paget's disease.Skeletal Radiol. 2007; 36: 609-626Crossref PubMed Scopus (51) Google Scholar, 3Roodman G.D. Windle J.J. Paget disease of bone.J. Clin. Invest. 2005; 115: 200-208Crossref PubMed Scopus (263) Google Scholar]. There is only limited evidence on Paget disease in other extant mammals, such as orangutans and lemurs [5Rothschild B.M. Martin L.D. Skeletal impact of disease.Bull. New Mexico Mus. Natl. Hist. 2006; 33: 1-226Google Scholar]. Paget disease has also been described in human bones dating back to the Neolithic [6Roches E. Blondiaux J. Cotton A. Chastanet P. Flipo R.M. Microscopic evidence for Paget's disease in two osteoarchaeological samples from early northern France.Int. J. Osteoarchaeol. 2002; 12: 229-234Crossref Scopus (17) Google Scholar]. Here, we report Paget disease in a vertebra of the Jurassic dinosaur Dysalotosaurus lettowvorbecki, representing the oldest indirect evidence of viruses in the fossil record.