Rapid identification of cytotoxic alkenyl catechols in Semecarpus anacardium using bioassay-linked high performance liquid chromatography-electrospray/mass spectrometric analysis
1999; Wiley; Volume: 10; Issue: 4 Linguagem: Inglês
10.1002/(sici)1099-1565(199907/08)10
ISSN1099-1565
AutoresYoung G. Shin, Geoffrey A. Cordell, Yumi Dong, John M. Pezzuto, Achanta Venkata Narasimha Appa Rao, Mullangi Ramesh, Bobbala Ravi Kumar, Marupaka Radhakishan,
Tópico(s)Phytochemistry and biological activity of medicinal plants
ResumoTwo alkenyl catechols were rapidly identified as probable cytotoxic constituents from the petroleum ether extract of Semecarpus anacardium using HPLC–electrospray/MS analysis linked to bioassay. These compounds were then isolated from the same extract using semi-prep HPLC and were proven to be 1,2-dihydroxy-3-pentadeca-7′,10′-dienylbenzene and 1,2-dihydroxy-3-pentadec-8′-enylbenzene, respectively, by comparison with physico-chemical data in the literature. Both isolates showed cytotoxic activities against a panel of human cancer cell lines. Copyright © 1999 John Wiley & Sons, Ltd.
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