Portal de Periódicos da CAPES

Clathrin: anatomy of a coat protein

1999; Elsevier BV; Volume: 9; Issue: 9 Linguagem: Inglês

10.1016/s0962-8924(99)01631-1

1879-3088

Corinne J. Smith, Barbara M. F. Pearse,

Protein Structure and Dynamics

Abstract Clathrin is a vesicle coat protein involved in the assembly of membrane and cargo into transport vesicles at the plasma membrane and on certain intracellular organelles. Recently, crystal structures of two separate parts of the clathrin heavy chain, a fragment of the proximal leg and the N-terminal domain, have been analysed, providing the first high-resolution data for a vesicle coat protein. Viewing these structures in the context of a hexagonal barrel coat, recently determined to 21 Å by cryo-electron microscopy, provides new insights into the assembly of clathrin coats.