Aggregation Behavior of Bile Salts in Aqueous Solution†‡
1996; Elsevier BV; Volume: 85; Issue: 1 Linguagem: Inglês
10.1021/js950326j
ISSN1520-6017
AutoresAdela Coello, Francisco Meijide, Eugenio Rodríguez Núñez, José Vázquez Tato,
Tópico(s)Thermodynamic properties of mixtures
ResumoFreezing point depression, ∆Tlk, and pNa are measured and analyzed for aqueous solutions of trihydroxy (NaTC) and dihydroxy (NaDC and NaTDC) bile salts. The results show the existence of break points in the plot of ∆Tlk vs molality at 0.018, 0.013, and 0.007 m, respectively, in good agreement with previous published critical micelle concentration values. Above the break point bile salts form aggregates with average aggregation numbers of 2.59 ± 0.12 (NaTC), 5.82 ± 0.04 (NaDC), and 5.42 ± 0.47 (NaTDC). Fractions of bound counterions are also deduced, being close to 0.3 for the three bile salts studied. This indicates that only one counterion is bound for every three monomers in the aggregate. The different structural models published for the bile salt aggregates are discussed.
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