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BIBTEX RIS

989 BUDESONIDE 3MG TID IS SUPERIOR TO PREDNISONE IN COMBINATION WITH AZATHIOPRINE IN THE TREATMENT OF AUTOIMMUNE HEPATITIS

2008; Elsevier BV; Volume: 48; Linguagem: Inglês

10.1016/s0168-8278(08)60991-5

1600-0641

Michael P. Manns, Mathias Bähr, Marek Woynarowski, Wolfgang Kreisel, Ran Oren, Rolf W. Günther, R. Hultcrantz, Markus Proels, C. Rust, Ulrich Spengler, F Szalay,

Hepatitis B Virus Studies

Background: EPIC3 includes a prospective trial assessing the safety and efficacy of retreatment of NRs with PegIntron/Rebetol (P/R).Aim: To determine SVR rates among Peg2a/2b (n = 820) and alfainterferon (n = 1203) NRs retreated with P/R and to evaluate predictors of SVR.Methods: NRs or those who relapsed after previous I/R treatment and had Metavir F2-F4 fibrosis received PegIntron 1.5 microgram/kg/wk plus Rebetol 800-1400 mg/d for up to 48 weeks.Plasma HCV-RNA was assessed at treatment weeks (TW)12, 24, and 48 and follow-up weeks 12 and 24 by quantitative Taq-Man assay (SPRI; sensitivity 125 IU/mL).