Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Neutrophils mediate antibody-induced antitumor effects in mice

2013; Elsevier BV; Volume: 122; Issue: 18 Linguagem: Inglês

10.1182/blood-2013-04-497446

ISSN

1528-0020

Autores

Marcello Albanesi, David A. Mancardi, Friederike Jönsson, Bruno Iannascoli, Laurence Fiette, James P. Di Santo, Clifford A. Lowell, Pierre Bruhns,

Tópico(s)

Cell Adhesion Molecules Research

Resumo

Key Points Neutrophils are necessary and sufficient for mAb-induced therapy of subcutaneous syngeneic or xenograft tumors in mice. Antitumor immunoglobulin G mAb therapy requires a Syk-dependent FcγR-induced killing of tumors by neutrophils.

Referência(s)