Portal de Periódicos da CAPES

SuperQuat, (S)-4-benzyl-5,5-dimethyl-oxazolidin-2-one for the asymmetric synthesis of α-substituted-aldehydes

2000; Elsevier BV; Volume: 11; Issue: 17 Linguagem: Inglês

10.1016/s0957-4166(00)00333-5

1362-511X

Steven D. Bull, Stephen G. Davies, Rebecca L. Nicholson, Hitesh J. Sanganee, Andrew D. Smith,

Synthetic Organic Chemistry Methods

Reduction of α-substituted-(S)-N-acyl-4-benzyl-5,5-dimethyl-oxazolidin-2-ones with DIBAL-H in CH2Cl2 affords α-substituted aldehydes with no loss of stereochemical integrity at their α-centre.