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Prediction of Sentinel Lymph Node Positivity by Growth Rate of Cutaneous Melanoma

2012; American Medical Association; Volume: 148; Issue: 5 Linguagem: Inglês

10.1001/archdermatol.2011.2522

1538-3652

A. Tejera‐Vaquerizo, Eduardo Nagore, Enrique Herrera‐Acosta, A. Martorell, Paula Martín-Cuevas, V. Través, Enrique Herrera‐Ceballos,

Cell Image Analysis Techniques

To determine whether growth rate (GR) of cutaneous melanoma predicts the histological sentinel lymph node (SLN) positivity.Retrospective cohort study.Two tertiary melanoma referral centers.A total of 698 patients with invasive primary cutaneous melanoma in whom the SLN was identified between January 1, 2000, and June 30, 2010.Based on previous studies, a surrogate measure for GR in primary invasive melanoma was calculated as the ratio of Breslow thickness to time to melanoma development.The SLN was positive in 20.2% of patients. Multivariate logistic regression analysis revealed that GR, Breslow thickness, and the presence of microscopic satellitosis were independently associated with SLN positivity. The probability of SLN positivity was 8.2% for slow-growth melanomas ( 0.50 mm/mo). Growth rate was not an independent predictive factor for survival.Growth rate of primary cutaneous melanoma, together with Breslow thickness and the presence of microscopic satellitosis, predicts the histological SLN positivity.