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Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode

2007; Elsevier BV; Volume: 18; Issue: 1 Linguagem: Inglês

10.1016/j.bmcl.2007.10.076

1464-3405

Richard Angell, Paul Bamborough, Anne Cleasby, Stuart Cockerill, Katherine L. Jones, Christopher J. Mooney, D.O. Somers, Ann L. Walker,

Synthesis of Tetrazole Derivatives

The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.