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Stabilization of DNA duplexes by covalently-linked peptides

2004; Elsevier BV; Volume: 60; Issue: 25 Linguagem: Inglês

10.1016/j.tet.2004.04.053

1464-5416

Vicente Marchán, Laurent Debéthune, Enrique Pedroso, Anna Grandas,

RNA Interference and Gene Delivery

The hybridization properties of various peptide–oligonucleotide hybrids were assessed from UV thermal denaturation experiments. Analysis of these and other published data suggests that peptide chains, both hydrophobic and positively charged, generally have a clear stabilizing effect on short-chain oligonucleotide duplexes.