Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

2014; Elsevier BV; Volume: 2; Issue: 6 Linguagem: Inglês

10.1016/s2213-8587(14)70050-6

ISSN

2213-8595

Autores

Kaixin Zhou, Louise A. Donnelly, Jian Yang, Miaoxin Li, Harshal Deshmukh, Natalie Van Zuydam, Emma Ahlqvist, Chris C. A. Spencer, Leif Groop, Andrew D. Morris, Helen M. Colhoun, Pak C. Sham, Mark I. McCarthy, Nicholette D. Palmer, Ewan R. Pearson,

Tópico(s)

Metabolism, Diabetes, and Cancer

Resumo

Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.

Referência(s)