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Ca2+ and synaptic plasticity

2005; Elsevier BV; Volume: 38; Issue: 3-4 Linguagem: Inglês

10.1016/j.ceca.2005.06.013

1532-1991

Michele Cavazzini, Tim Bliss, Nigel J. Emptage,

Neuroscience and Neural Engineering

The induction and maintenance of synaptic plasticity is well established to be a Ca2+-dependent process. The use of fluorescent imaging to monitor changes [Ca2+]i in neurones has revealed a diverse array of signaling patterns across the different compartments of the cell. The Ca2+ signals within these compartments are generated by voltage or ligand-gated Ca2+ influx, and release from intracellular stores. The changes in [Ca2+]i are directly linked to the activity of the neurone, thus a neurone's input and output is translated into a dynamic Ca2+ code. Despite considerable progress in measuring this code much still remains to be determined in order to understand how the code is interpreted by the Ca2+ sensors that underlie the induction of compartment-specific plastic changes.