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Cyclic Guanosine Monophosphate: Elevation in Degenerating Photoreceptor Cells of the C3H Mouse Retina

1974; American Association for the Advancement of Science; Volume: 186; Issue: 4162 Linguagem: Inglês

10.1126/science.186.4162.449

1095-9203

Debora B. Farber, Richard N. Lolley,

Adenosine and Purinergic Signaling

As a result of an early deficiency in cyclic nucleotide phosphodiesterase activity, guanosine 3′,5′-monophosphate accumulates in retinal photoreceptor cells before they begin to degenerate. It is suggested that degeneration of the photoreceptor cells is related to an imbalance in their metabolism or function which is caused by the elevated levels of cyclic guanosine monophosphate.