Portal de Periódicos da CAPES

STUDIES ON DESTRUCTION OF RED BLOOD CELLS

1939; Volume: 64; Issue: 6 Linguagem: Inglês

10.1001/archinte.1939.00190060140010

0730-188X

Thomas Hale Ham,

Erythrocyte Function and Pathophysiology

The disease syndrome of chronic hemolytic anemia associated with paroxysmal nocturnal hemoglobinuria was described as a separate entity in 1928 and 1931 by Marchiafava 1 and in 1931 by Micheli. 2 The clinical manifestations have been reviewed recently with the report of cases by Witts 3 and by Hamburger and Bernstein. 4 The pathologic observations in 2 cases, with a review of the literature, were reported in 1938 by Scott, Robb-Smith and Scowen. 5 Van den Bergh 6 in 1911 made important observations on the in vitro manifestations of this disease without distinguishing it from acholuric hemolytic jaundice. A preliminary report on the mechanism of hemolysis was published in 1937 by Ham; 7 these observations were confirmed in 1938 by Dacie, Israels and Wilkinson. 8 Jordan 9 in 1938 published independent observations on the hemolytic mechanism. The present communication deals with the relation of the acid-base equilibrium of blood to hemolysis in vivo and in vitro and with observations