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Comparison of the Anticonflict Effect of Buspirone and Its Major Metabolite l-(2-Pyrimidinyl)-Piperazine (1-PP) in Rats

1993; Japanese Pharmacological Society; Volume: 62; Issue: 2 Linguagem: Inglês

10.1254/jjp.62.199

1347-3506

Manabu Amano, Arata Goto, Atsuko Sakai, Minako Achiha, Nee Hara, Norimitsu TAKAHASHI, Chiaki Hara, Nobuya Ogawa,

Phytochemistry and Biological Activities

Paeoniflorin, a major constituent of peony root, has been demonstrated to attenuate the radial maze performance deficit produced by scopolamine. In the present study, to investigate the possible involvement of beta-adrenergic systems in the paeoniflorin antagonism of the scopolamine deficit, the effects of two beta-adrenoceptor antagonists, propranolol and atenolol, on the paeoniflorin effect were examined in male Wistar rats. Paeoniflorin (1 mg/kg, p.o.) significantly attenuated the scopolamine HBr (0.3 mg/kg, i.p.)-induced deficit in the choice accuracy in radial maze performance without changing the running time prolonged by scopolamine. Neither D,L-propranolol HCl, a lipophilic beta-antagonist, at 3 mg/kg, i.p. nor atenolol, a hydrophilic beta 1-antagonist that is known to hardly ever cross the blood-brain barrier, at 1 mg/kg, i.p. impaired maze performance by itself or aggravated the scopolamine-induced deficit in radial maze performance. Both antagonists, however, completely blocked the antagonizing effect of paeoniflorin on the scopolamine deficit. These data suggest that the beta-adrenergic systems, especially peripheral beta 1-adrenergic systems, are involved in the antagonizing effect of paeoniflorin on the scopolamine deficit in radial maze performance in rats.