Clathrin coat construction in endocytosis
2000; Elsevier BV; Volume: 10; Issue: 2 Linguagem: Inglês
10.1016/s0959-440x(00)00071-3
ISSN1879-033X
Autores Tópico(s)Glycosylation and Glycoproteins Research
ResumoElectron cryomicroscopy of the clathrin coat and X-ray crystallography of parts of the clathrin heavy chain combine to give a detailed picture of the clathrin molecule, assembled as a cage. Recently determined domain structures of other components of the endocytic machinery, particularly the μ2 subunit and the α-appendage domain of the AP2 adaptor complex, provide important information on the sequence of recognition events involved in the dynamic process of clathrin coat assembly.
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