Asymmetric cyclopropanation of olefins with diazoacetate using chiral copper catalysts
1997; Elsevier BV; Volume: 53; Issue: 28 Linguagem: Inglês
10.1016/s0040-4020(97)00644-3
ISSN1464-5416
AutoresTsuyoshi Ichiyanagi, Makoto Shimizu, Tamotsu Fujisawa,
Tópico(s)Catalytic Alkyne Reactions
ResumoChiral 2-(2-aryl- or 2-alkyl-sufonylamino)phenyl-4-phenyl-1,3-oxazolines were found to be effective ligands for copper-catalyzed enantioselective cyclopropanation reaction of olefins. The reaction of styrene with d-menthyl diazoacetate in the presence of optically active copper catalysts gave cyclopropanation products in a ratio of trans : cis = 83 : 17 with 63% cc (trans) and 84% cc (cis).
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