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Molecular genetics in the pediatric intensive care unit

2003; Elsevier BV; Volume: 19; Issue: 3 Linguagem: Inglês

10.1016/s0749-0704(03)00004-6

1557-8232

Thomas P. Shanley, Hector R. Wong,

Mitochondrial Function and Pathology

Historically, molecular genetics has been a foreign field to the pediatric ICU and the pediatric intensivist. During the last decade, however, molecular genetics and its principles have become integrated into all aspects of medicine, including pediatric critical care medicine. It behooves all pediatric intensivists to have at least a working knowledge of molecular genetics, because developments in that field will increasingly affect daily clinical practice and will be a driving force behind future advancements in the clinical care of critically ill children. Covering the entire field of molecular genetics is not feasible within the limited context of this article. The authors cover some basic principles and provide relevant examples of how molecular genetics is affecting critical care medicine today. The interested reader is referred to textbooks that cover the respective subjects in exhaustive detail.