Portal de Periódicos da CAPES

Emerging roles of ATF2 and the dynamic AP1 network in cancer

2009; Nature Portfolio; Volume: 10; Issue: 1 Linguagem: Inglês

10.1038/nrc2681

1474-1768

Pablo Lopez‐Bergami, Eric Lau, Ze’ev A. Ronai,

Ubiquitin and proteasome pathways

Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. This Perspective summarizes the emerging role of the transcription factor ATF2 as part of the AP1 complex in tumorigenesis. Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.