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Inhibition of HIV Fusion with Multivalent Gold Nanoparticles

2008; American Chemical Society; Volume: 130; Issue: 22 Linguagem: Inglês

10.1021/ja710321g

1943-2984

Mary-Catherine Bowman, T. Eric Ballard, Christopher J. Ackerson, Daniel L. Feldheim, David M. Margolis, Christian Melander,

Nanocluster Synthesis and Applications

The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721)-gold nanoparticle conjugates displayed activity comparable to that of TAK-779. This result suggests that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics.