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1H chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men

1999; Wiley; Volume: 42; Issue: 1 Linguagem: Inglês

10.1002/(sici)1522-2594(199907)42

1522-2594

Paul E. Sijens, Matthijs Oudkerk, F.E. de Leeuw, Jan Cees de Groot, Erik Achten, R. Heijboer, Albert Hofman, Monique M.B. Breteler,

Advanced Neuroimaging Techniques and Applications

1H magnetic resonance spectroscopy was used to compare brain metabolism in 540 elderly persons, stratified by sex and age (60–90 years old). An 8 × 8 × 2 cm3 supraventricular brain volume, a transverse plane parallel to the canthomeatal line, was examined by automated 1H chemical shift imaging [point-resolved spectroscopy (PRESS), TE of 35 msec]. Regional choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA) peak areas in the 518 successful examinations (96%) were studied by division through the total area of the particular metabolite in each spectral map. This procedure eliminated intersubject variance, maximized intervoxel variance (26 ≤ F ≤ 149, P < 0.0001) and reduced the standard deviations in the voxel metabolite signals threefold. Normalized signals in women (n = 257) and men (n = 261) differed in 9 (Cho/ΣCho), 8 (Cr/ΣCr), and 10 (NAA/ΣNAA) of 36 voxels examined (P ≤ 0.001). In the cingulate gyrus Cho/ΣCho, Cr/ΣCr, and NAA/ΣNAA were reduced in men compared with women. These findings are consistent with a sex-related reduction of glucose metabolism in the same brain lobe revealed by positron emission tomography. Magn Reson Med 42:24–31, 1999. © 1999 Wiley-Liss, Inc.