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Adeno-associated virus expression systems for gene transfer

1998; Elsevier BV; Volume: 9; Issue: 5 Linguagem: Inglês

10.1016/s0958-1669(98)80031-1

1879-0429

Joseph E. Rabinowitz, Jude Samulski,

RNA Interference and Gene Delivery

In contrast to other gene delivery systems, adeno-associated virus vectors show long term gene expression without immune response or toxicity. New production methods have increased vector titers and eliminated adenovirus contamination, thereby facilitating effective in vivo use. These advancements will expedite additional animal model studies providing validation for use of this vector in human clinical trials.