The effect of α-tocopherol on essential fatty acid oxidation in liver mitochondria from vitamin E-deficient chicks
1963; Elsevier BV; Volume: 102; Issue: 1 Linguagem: Inglês
10.1016/0003-9861(63)90323-0
ISSN1096-0384
AutoresHiroshi Kimura, Fred A. Kummerow,
Tópico(s)Vitamin C and Antioxidants Research
ResumoDevelopment of encephalomalacia in chicks seemed related to the depression of enzymic activity in the liver mitochondria. If injected intramuscularly at the first sign of symptoms, α-tocopherol alleviated the symptoms and restored enzyme activity. Furthermore, the liver mitochondria obtained from chicks which had received injections of α-tocopherol was not subject to peroxidation to any greater degree than the liver mitochondria obtained from chicks which had been kept on a vitamin E-supplemented diet. Lipid peroxidation was found to coincide with linoleate oxidation in the liver mitochondria of vitamin E-deficient chicks. The lipoperoxides seemed to inhibit coupling of an enzyme with cytochrome c and cytochrome a in the electron-transport system.
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