Determination of Aspirin, Salicylic Acid, Salicyluric Acid, and Gentisic Acid in Human Plasma and Urine by High Pressure Liquid Chromatography
1979; Taylor & Francis; Volume: 12; Issue: 6 Linguagem: Inglês
10.1080/00032717908055714
ISSN1532-236X
AutoresEdwin N. Amick, William D. Mason,
Tópico(s)Analytical Chemistry and Sensors
ResumoAbstract A method has been developed to simultaneously determine aspirin, salicylic acid, salicyluric acid, and gentisic acid concentrations in human plasma and urine. An extraction and dry-down step prepare the sample for resolution by reverse-phase high pressure liquid chromatography. The column effluent is monitored by both ultraviolet absorbance and fluorescence to optimize sensitivity and specificity for the compounds of interest.
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