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α-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae)

2007; Elsevier BV; Volume: 68; Issue: 5 Linguagem: Inglês

10.1016/j.phytochem.2006.12.015

1873-3700

Luc Meva’a Mbaze, Hervé Martial Poumale Poumale, Jean Duplex Wansi, Jean Alexandre Lado, Shamsun Nahar Khan, Muhammad Choudhary Iqbal, Bonaventure T. Ngadjui, Hartmut Laatsch,

Bioactive Compounds and Antitumor Agents

In addition to fatty acids, a mixture of sterols (beta-sitosterol, stigmasterol, campesterol and stigmastanol), lupeol, arctigenin methylether, sesamin, vanillic acid (1), 2,6-dimethoxy-1,4-benzoquinone (2), betulinic acid and two pentacyclic triterpene acetates were isolated from Fagara tessmannii Engl. They were identified as 3beta-acetoxy-16beta-hydroxybetulinic acid (3a) and 3beta,16beta-diacetoxybetulinic acid (3b), and their structures were established using 1 and 2D NMR spectra and by comparison with published data. Two derivatives of the compounds were prepared. Some isolated compounds were evaluated for their antifungal and antibacterial activities. Compounds 1 and 3a showed significant inhibition of alpha-glucosidase.