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Synthesis and SAR of diiodotyrosine-derived glycine-site N-methyl-D-aspartate receptor ligands

1996; Elsevier BV; Volume: 6; Issue: 10 Linguagem: Inglês

10.1016/0960-894x(96)00187-4

1464-3405

Neil R. Curtis, Janusz J. Kulagowski, Paul D. Leeson, Ian M. Mawer, Mark P. Ridgill, Michael Rowley, Sarah Grimwood, George Marshall,

Molecular spectroscopy and chirality

Abstract A series of analogues of the novel diiodotyrosine derived NMDA glycine-site ligand (R)-4 was prepared in which the aryl substitution, chain length and amino acid groups were varied. The key structural features for binding are the α-amino acid function, having the (R) absolute stereochemistry, the 3,5-diiodo substituted aromatic ring and a lipophilic group attached at the phenolic oxygen of the tyrosine moiety.