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Proteolysis and cell migration: creating a path?

1999; Elsevier BV; Volume: 11; Issue: 5 Linguagem: Inglês

10.1016/s0955-0674(99)00022-8

1879-0410

Gillian Murphy, Jelena Gavrilović,

Peptidase Inhibition and Analysis

Both serine and metalloproteinases have been implicated in the complex integrated events underlying cell migration but no definitive single mechanism has emerged. Work over the past two years linking both membrane and soluble proteinases with integrins and other adhesion proteins and with intracellular signalling systems could herald the beginnings of a potential expansion of our understanding of the role and regulation of proteolysis in cell migration.