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Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents

2002; Elsevier BV; Volume: 58; Issue: 32 Linguagem: Inglês

10.1016/s0040-4020(02)00628-2

1464-5416

Ian R. Baxendale, Steven V. Ley, Marcella Nessi, Claudia Piutti,

Psychedelics and Drug Studies

In this report we describe in full the total synthesis of the amaryllidaceae alkaloid (+)-plicamine 1 including a model compound study. In both cases the compounds were prepared using solid-supported reagents and scavengers in multi-step sequences of reactions to give materials which required no conventional purification but could be carried on to the next synthetic step.