Carnosine and taurine protect rat cerebellar granular cells from free radical damage
1999; Elsevier BV; Volume: 263; Issue: 2-3 Linguagem: Inglês
10.1016/s0304-3940(99)00150-0
ISSN1872-7972
AutoresА. А. Болдырев, P. S. Johnson, Yanzhang Wei, Yuansheng Tan, David O. Carpenter,
Tópico(s)Stress Responses and Cortisol
ResumoCarnosine and taurine have been suggested to protect excitable tissues against oxidative stress. We have investigated the protection of cerebellar granule cells (neurons) by these compounds against free radicals generated by kainic acid (KA), and 3-morpholinosydnonimine hydrochloride (SIN-1) treatment. Carnosine decreased free radical levels in KA and SIN-1 treated cells, and increased cell viability. The KA effect, but not that of SIN-1, was dependent on the presence of external Ca2+ ions. Taurine increased cell viability, but did not decrease free radical levels. These results suggest that there are multiple pathways leading to cell death, not all of which involve decreases in intracellular free radical levels, and also indicate that multiple mechanisms of cellular defense exist against oxidative stress.
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