A Variable Age of Onset Segregation Model for Linkage Analysis, with Correction for Ascertainment, Applied to Glioma
2012; American Association for Cancer Research; Volume: 21; Issue: 12 Linguagem: Inglês
10.1158/1055-9965.epi-12-0703
ISSN1538-7755
AutoresXiangqing Sun, Jaime Vengoechea, Robert C. Elston, Yanwen Chen, Christopher I. Amos, Georgina Armstrong, Jonine L. Bernstein, Elizabeth B. Claus, Faith G. Davis, Richard S. Houlston, Dora Il’yasova, Robert B. Jenkins, Christoffer Johansen, Rose Lai, Ching C. Lau, Yanhong Liu, Bridget J. McCarthy, Sara H. Olson, Siegal Sadetzki, Joellen Schildkraut, Sanjay Shete, Robert Yu, Nicholas A. Vick, Ryan Merrell, Margaret Wrensch, Ping Yang, Beatrice Melin, Melissa L. Bondy, Jill S. Barnholtz‐Sloan,
Tópico(s)Chromatin Remodeling and Cancer
ResumoWe propose a 2-step model-based approach, with correction for ascertainment, to linkage analysis of a binary trait with variable age of onset and apply it to a set of multiplex pedigrees segregating for adult glioma.
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