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Plasma Prorenin and Renin in Childhood and Adolescence

1988; American Medical Association; Volume: 142; Issue: 10 Linguagem: Inglês

10.1001/archpedi.1988.02150100064027

1538-3628

Darrell M. Wilson,

Neonatal Respiratory Health Research

We studied 108 subjects (age range, 4 to 76 years) to determine the effect of age on prorenin (inactive renin), active renin, and plasma renin activity in normal children, adolescents, and adults. Children and adolescents had lower prorenin concentrations and higher plasma renin activity and active renin concentrations than did adults. Prorenin concentrations were positively correlated with age over the range of 4 to 76 years, while plasma renin activity and active renin concentration were negatively correlated with age. Plasma prorenin and active renin concentrations from umbilical cord blood samples obtained from 11 newborns and arterial samples obtained from five infants were higher than those in samples obtained from children or adults.