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Transcriptomic Profiling in Childhood H1N1/09 Influenza Reveals Reduced Expression of Protein Synthesis Genes

2013; Oxford University Press; Volume: 208; Issue: 10 Linguagem: Inglês

10.1093/infdis/jit348

1537-6613

Jethro Herberg, Myrsini Kaforou, Stuart Gormley, Edward R. Sumner, Sanjay Patel, Kelsey Jones, Stéphane Paulus, Colin G. Fink, Federico Martinón‐Torres, Giovanni Montana, Victoria Wright, Michael Levin,

interferon and immune responses

We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterized the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalized with H1N1/09 infection.