Schwann Cell to Axon Transfer of Ribosomes: Toward a Novel Understanding of the Role of Glia in the Nervous System
2008; Society for Neuroscience; Volume: 28; Issue: 43 Linguagem: Inglês
10.1523/jneurosci.2429-08.2008
ISSN1529-2401
AutoresFelipe A. Court, William T. Hendriks, Harold D. MacGillavry, Jaime Álvarez, Jan van Minnen,
Tópico(s)Virus-based gene therapy research
ResumoSchwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons are desomatized (severed from their cell bodies). We furthermore demonstrate, using the Wallerian degeneration slow mouse as a model, that Schwann cells transfer polyribosomes to desomatized axons. These data indicate that Schwann cells have the propensity to control axonal protein synthesis by supplying ribosomes on local basis.
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