Oxidation of methyl p-tolyl sulfide with bakers' yeast: preparation of a synthon of the mevinic acid-type hypocholestemic agents
1995; Issue: 13 Linguagem: Inglês
10.1039/p19950001641
ISSN2050-8255
AutoresJean Beecher, Ian Brackenridge, Stanley M. Roberts, Jenny Tang, Andrew Willetts,
Tópico(s)Oxidative Organic Chemistry Reactions
ResumoBakers' yeast oxidized methyl p-tolyl sulfide to produce the R-sulfoxide 1 in good yield and high enantiomeric excess; the sulfoxide 1 was used to prepare (4R,6S)-tert-butyldimethylsilyloxy-6-hydroxymethyltetrahydropyran-2-one 15.
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