A regioselective three-component reaction for synthesis of novel 1′H-spiro[isoindoline-1,2′-quinazoline]-3,4′(3′H)-dione derivatives
2009; Elsevier BV; Volume: 65; Issue: 18 Linguagem: Inglês
10.1016/j.tet.2009.02.037
ISSN1464-5416
AutoresAli A. Mohammadi, Minoo Dabiri, H. Qaraat,
Tópico(s)Cancer therapeutics and mechanisms
ResumoA ring opening and regioselective three-component reaction of isatoic anhydride, isatins, and aromatic or aliphatic primary amines in the presence of catalytic amount of KAl(SO4)2·12H2O (alum) to yield a novel series of 1′H-spiro[isoindoline-1,2′-quinazoline]-3,4′(3′H)-dione is described.
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