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BIBTEX RIS

A Dirofilaria immitis Polyprotein Up-Regulates Nitric Oxide Production

2002; American Society for Microbiology; Volume: 70; Issue: 9 Linguagem: Inglês

10.1128/iai.70.9.5283-5286.2002

ISSN

1098-5522

Autores

Hiroyuki Tezuka, Shinjiro Imai, Setsuko Tsukidate, Koichirô Fujita,

Tópico(s)

Invertebrate Immune Response Mechanisms

Resumo

ABSTRACT We investigated the effect of recombinant Dirofilaria immitis polyprotein (rDiAg) on nitric oxide (NO) production by peritoneal macrophages. rDiAg induced NO production by macrophages from wild-type and lipopolysaccharide-hyporesponsive C3H/HeJ, but not CD40 −/− , mice. These results suggest that CD40 is involved in rDiAg-driven NO production by murine macrophages.

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