In Vitro Development of Resistance to Six Quinolones in Streptococcus pneumoniae, Streptococcus pyogenes , and Staphylococcus aureus
2001; American Society for Microbiology; Volume: 45; Issue: 3 Linguagem: Inglês
10.1128/aac.45.3.938-942.2001
ISSN1098-6596
AutoresMechthild Boos, Susanne Mayer, Ansgar Fischer, Karl Köhrer, Sibylle Scheuring, Peter Heisig, J. Verhoef, Ad C. Fluit, Franz‐Josef Schmitz,
Tópico(s)Antibiotic Resistance in Bacteria
ResumoStreptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus isolates were exposed to subinhibitory MICs of ciprofloxacin, sparfloxacin, gatifloxacin, moxifloxacin, clinafloxacin, and gemifloxacin during a 10-day period. Subculturing led to resistance development, regardless of the initial potencies of the quinolones. None of the quinolones was associated with a significantly slower rate of resistance development.
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