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Forty Years of Clathrin‐coated Vesicles

2015; Wiley; Volume: 16; Issue: 12 Linguagem: Inglês

10.1111/tra.12335

1600-0854

Margaret S. Robinson,

Lipid Membrane Structure and Behavior

The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975 was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered the molecular details of clathrin and its associated proteins, including how they assemble into a coated vesicle and how they select cargo. Unexpected connections have been found with signalling, development, neuronal transmission, infection, immunity and genetic disorders. But there are still a number of unanswered questions, including how clathrin‐mediated trafficking is regulated and how the machinery evolved.