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Voriconazole Use for Endemic Fungal Infections

2009; American Society for Microbiology; Volume: 53; Issue: 4 Linguagem: Inglês

10.1128/aac.01148-07

1098-6596

Alison G. Freifeld, Laurie A. Proia, David R. Andes, Larry M. Baddour, Janis E. Blair, Brad Spellberg, Sandra R. Arnold, Arnold Lentnek, L. Joseph Wheat,

Infectious Diseases and Mycology

In a retrospective review of 24 patients with histoplasmosis, blastomycosis, or coccidioidomycosis treated with voriconazole (most for salvage therapy), the outcome was favorable (improved or stable) for 22 (95.8%) within 2 months of starting voriconazole and for 20 (83.3%) at the last follow-up. Prospective studies are required to determine its role in the treatment of endemic mycoses.