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Bioavailability and its assessment

2004; Wiley; Volume: 27; Issue: 6 Linguagem: Inglês

10.1111/j.1365-2885.2004.00604.x

1365-2885

Pierre‐Louis Toutain, Alain Bousquet‐mélou,

Analytical Methods in Pharmaceuticals

Bioavailability is a key pharmacokinetic parameter which expresses the proportion of a drug administered by any nonvascular route that gains access to the systemic circulation. Presented in this review are the different approaches to measurement of bioavailability (absolute and relative), including the case in which intravenous administration is impossible. The rate of drug absorption is also discussed with special emphasis on the possible difficulties encountered using C max and T max or curve fitting to evaluate the rate of drug absorption.