C2 Symmetric chiral N-heterocyclic carbene catalyst for asymmetric intramolecular Stetter reaction
2006; Elsevier BV; Volume: 47; Issue: 33 Linguagem: Inglês
10.1016/j.tetlet.2006.06.080
ISSN1873-3581
AutoresYasumasa Matsumoto, Kiyoshi Tomioka,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoThe asymmetric intramolecular Stetter reaction of ω-formyl α,β-unsaturated carbonyl compounds was catalyzed by a C2 symmetric chiral carbene, generated from (4S,5S)-diphenyl-1,3-bis(mesitylmethyl)-4,5-dihydro-1H-imidazolium tetrafluoroborate, to afford 2-substituted cyclopentanones in good enantioselectivity of up to 80%.
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