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Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin

1996; Portland Press; Volume: 314; Issue: 2 Linguagem: Inglês

10.1042/bj3140401

1470-8728

Dean B. Reardon, Steven L. Wood, David L. Brautigan, Graeme I. Bell, Paul Dent, Thomas W. Sturgill,

Protein Kinase Regulation and GTPase Signaling

Human somatostatin receptor 3 (‘hsstr3’) was transiently expressed in NIH 3T3 cells stably transformed with Ha-Ras (G12V). Somatostatin activated a protein tyrosine phosphatase, and inactivated the constitutively active, membrane-associated form of the Raf-1 serine kinase present in these cells in vivo and in vitro.